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  • Drug Selectivity : An Evolving Concept in Medicinal Chemistry
    Drug Selectivity : An Evolving Concept in Medicinal Chemistry

    The book "Drug Selectivity - An Evolving Concept in Medicinal Chemistry" provides a current overview and comprehensive compilation for medicinal chemists that discusses the effects of aiming for multiple targets on the entire drug development process. The result is a broad survey of current and future strategies for drug selectivity in medicinal chemistry with theoretical but also practical aspects.Different strategies are presented and evaluated, such as various design approaches, merged multiple ligands, discovery technologies and a broad range of successful examples of unselective drugs taken from all major disease areas.With its wide-ranging view of an emerging new paradigm in drug development, this handbook is of prime importance for every medicinal and pharmaceutical chemist.

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    Opt for a touch of serenity at home with cutting board, coaster of 'Quotes' model 'Good cooking is honest, sincere and simple'. Glass. Size: 30x20cm. French creation Collection: Quotes Color (s): black Material: Glass Audience: Female Dimensions: Length: 300mm, Height: 200mm

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  • What is selectivity in electrical engineering?

    Selectivity in electrical engineering refers to the ability of a system or device to respond to specific signals while ignoring others. It is a measure of how well a system can discriminate between different frequencies or channels. Selectivity is important in applications such as filtering out unwanted noise or interference in communication systems, allowing for the desired signal to be received or transmitted effectively. In electrical engineering, selectivity is often achieved through the use of filters or other signal processing techniques.

  • What is the selectivity of reinsurance?

    The selectivity of reinsurance refers to the process of choosing which risks to transfer to a reinsurer based on specific criteria. Reinsurers typically select risks that align with their underwriting guidelines, risk appetite, and financial capacity. By being selective in the risks they assume, reinsurers can manage their exposure to catastrophic events and ensure a balanced portfolio. This selectivity helps reinsurers maintain profitability and stability in the face of unpredictable events.

  • What does selectivity mean in LS switches?

    Selectivity in LS switches refers to the ability of the switch to accurately and efficiently route signals to their intended destination while minimizing interference or crosstalk with other signals. A highly selective LS switch will have low insertion loss and high isolation between channels, ensuring that signals remain clean and intact throughout the switching process. This is crucial in applications where multiple signals need to be switched simultaneously without compromising signal integrity.

  • What is the selectivity of pre-insurance?

    The selectivity of pre-insurance refers to the process of evaluating and selecting individuals or groups who are eligible for insurance coverage based on certain criteria. This helps insurance companies manage risk by only insuring individuals who are less likely to make claims or pose a higher risk. By carefully selecting who can obtain insurance coverage, insurance companies can maintain a balanced risk pool and offer competitive premiums to their policyholders.

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  • Real Games : What's Legitimate and What's Not in Contemporary Videogames
    Real Games : What's Legitimate and What's Not in Contemporary Videogames

    How we talk about games as real or not-real, and how that shapes what games are made and who is invited to play them. In videogame criticism, the worst insult might be "That's not a real game!" For example, "That's not a real game, it's on Facebook!" and "That's not a real game, it's a walking simulator!" But how do people judge what is a real game and what is not-what features establish a game's gameness?In this engaging book, Mia Consalvo and Christopher Paul examine the debates about the realness or not-realness of videogames and find that these discussions shape what games get made and who is invited to play them. Consalvo and Paul look at three main areas often viewed as determining a game's legitimacy: the game's pedigree (its developer), the content of the game itself, and the game's payment structure.They find, among other things, that even developers with a track record are viewed with suspicion if their games are on suspect platforms.They investigate game elements that are potentially troublesome for a game's gameness, including genres, visual aesthetics, platform, and perceived difficulty. And they explore payment models, particularly free-to-play-held by some to be a marker of illegitimacy.Finally, they examine the debate around such so-called walking simulators as Dear Esther and Gone Home. And finally, they consider what purpose is served by labeling certain games "real."

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  • Legitimate Opposition
    Legitimate Opposition

    The first theory of legitimate opposition in fifty years In political systems defined by legitimate opposition, those who hold power allow their rivals to peacefully challenge and displace them, and those who have lost power do not seek to sabotage the winners.Legitimate opposition came under assault at the American capitol on January 6, 2021, and is menaced by populists and autocrats across the globe. Alexander Kirshner provides the first sustained theory of legitimate opposition since the Cold War.On the orthodox view, democracy is lost when legitimate opposition is subverted.But efforts to reconcile opposition with democracy fail to identify the value of the frequently imperfect, unfair, and inegalitarian real-world practice.Marshaling a revisionist reconstruction of opposition’s history, Kirshner provides a new account of opposition’s value fit for the twenty-first century and shows why, given the difficult conditions of political life, legitimate opposition is an achievement worth defending.

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  • What does selectivity mean in circuit breakers?

    Selectivity in circuit breakers refers to the ability of the breakers to isolate and disconnect only the faulty section of the electrical system while leaving the rest of the system operational. This is important in preventing unnecessary power outages and disruptions to the entire system. Selectivity allows for a more targeted and efficient response to electrical faults, minimizing downtime and maximizing the reliability of the electrical system. It also helps in identifying and addressing the specific issue without affecting the rest of the system.

  • What is selectivity among electrical engineering components?

    Selectivity among electrical engineering components refers to the ability of a component to respond to specific signals or frequencies while ignoring others. This is important in applications where different signals need to be processed or filtered selectively. Components like filters, amplifiers, and sensors can exhibit selectivity based on their design and characteristics, allowing them to perform specific functions within a circuit or system. By controlling the selectivity of components, engineers can tailor the performance of a system to meet desired specifications and requirements.

  • What is the selectivity in FI switches?

    Selectivity in FI switches refers to the ability of the switch to accurately and reliably detect the presence of a fault in the protected circuit while ignoring normal transient disturbances. This means that the switch can distinguish between a genuine fault and harmless fluctuations in the system, ensuring that it only operates when necessary to isolate the fault and maintain the continuity of the power supply. High selectivity is essential for the reliable and efficient operation of FI switches in protecting electrical circuits and preventing electrical hazards.

  • What is the selectivity of a circuit breaker?

    The selectivity of a circuit breaker refers to its ability to isolate and disconnect only the faulty section of a circuit while allowing the rest of the system to continue functioning. This is important in preventing unnecessary power outages and disruptions. Selectivity is achieved by setting different time-current characteristics for each circuit breaker in a system, ensuring that the breaker closest to the fault operates first without affecting other parts of the system.

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